The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ABCA5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ABCA5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ABCA5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:69,047,005–69,048,281 | 279.4 kb | Distal (>10kb) Multiome | 679 | |
| chr17:69,326,154–69,327,854 | 79 bp | At TSS Multiome | 969 | |
| chr17:69,335,155–69,335,317 | 8.0 kb | Proximal (<10kb) | 100 | |
| chr17:69,412,260–69,413,562 | 85.5 kb | Distal (>10kb) Multiome | 184 | |
| chr17:69,414,033–69,415,228 | 87.5 kb | Distal (>10kb) Multiome | 574 | |
| chr17:69,448,378–69,449,196 | 121.6 kb | Distal (>10kb) Multiome | 238 | |
| chr17:69,466,526–69,467,765 | 140.3 kb | Distal (>10kb) Multiome | 254 | |
| chr17:71,032,277–71,033,889 | 1705.8 kb | Distal (>10kb) Multiome HiCAR | 450 |
Genomic view of the ABCA5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.