AARSD1
alanyl-tRNA synthetase domain containing 1 | AlaXp, MGC2744

Predicted to enable Ser-tRNA(Ala) deacylase activity. Predicted to be involved in regulation of translational fidelity. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.3
Biological processes 17 terms
ATP binding (GO:0005524)Ser-tRNA(Ala) deacylase activity (GO:0002196)Ser-tRNA(Ala) deacylase activity (GO:0002196)alanine-tRNA ligase activity (GO:0004813)alanyl-tRNA aminoacylation (GO:0006419)aminoacyl-tRNA deacylase activity (GO:0002161)aminoacyl-tRNA ligase activity (GO:0004812)aminoacyl-tRNA metabolism involved in translational fidelity (GO:0106074)biological_process (GO:0008150)cytoplasm (GO:0005737)molecular_function (GO:0003674)nucleic acid binding (GO:0003676)nucleotide binding (GO:0000166)nucleus (GO:0005634)protein binding (GO:0005515)regulation of translational fidelity (GO:0006450)tRNA aminoacylation (GO:0043039)
Expression (TPM)
AARSD1 — as a Regulated Gene

TFs regulating AARSD1 0 TFs

Transcription factors with Perturb-seq knockdown data for AARSD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AARSD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to AARSD1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AARSD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:42,669,472–42,671,112 293.7 kb Distal (>10kb) Multiome 230
chr17:42,673,584–42,674,462 290.4 kb Distal (>10kb) Multiome 296
chr17:42,674,847–42,675,579 289.2 kb Distal (>10kb) Multiome 194
chr17:42,676,055–42,678,790 287.3 kb Distal (>10kb) Multiome 1070
chr17:42,679,005–42,680,519 284.5 kb Distal (>10kb) Multiome 654
chr17:42,682,736–42,683,400 281.7 kb Distal (>10kb) Multiome 480
chr17:42,744,352–42,745,375 219.5 kb Distal (>10kb) Multiome 966
chr17:42,761,003–42,761,468 203.4 kb Distal (>10kb) Multiome 335
chr17:42,780,029–42,780,899 183.9 kb Distal (>10kb) Multiome 712
chr17:42,798,408–42,798,877 165.7 kb Distal (>10kb) Multiome 866
chr17:42,823,968–42,824,503 140.1 kb Distal (>10kb) Multiome 829
chr17:42,832,889–42,833,841 131.1 kb Distal (>10kb) Multiome 980
chr17:42,964,237–42,964,843 58 bp At TSS Multiome 655
chr17:42,979,966–42,981,044 16.0 kb Distal (>10kb) Multiome 843
chr17:42,997,598–42,998,917 33.9 kb Distal (>10kb) Multiome 1112
chr17:43,021,026–43,022,568 57.9 kb Distal (>10kb) Multiome 973
chr17:43,024,255–43,025,752 60.6 kb Distal (>10kb) Multiome 811
chr17:43,124,981–43,125,702 161.0 kb Distal (>10kb) Multiome 837
chr17:43,169,744–43,171,576 206.7 kb Distal (>10kb) Multiome 1018
chr17:43,211,494–43,212,392 247.5 kb Distal (>10kb) Multiome 586

Genome Browser

Genomic view of the AARSD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:42,659,472 – 43,222,392
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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