This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for AAR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AAR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AAR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:35,953,663–35,955,230 | 281.9 kb | Distal (>10kb) Multiome | 1166 | |
| chr20:36,010,700–36,011,324 | 225.5 kb | Distal (>10kb) Multiome | 70 | |
| chr20:36,050,468–36,051,316 | 185.5 kb | Distal (>10kb) Multiome | 1033 | |
| chr20:36,064,282–36,065,619 | 171.7 kb | Distal (>10kb) Multiome | 798 | |
| chr20:36,092,411–36,092,942 | 143.9 kb | Distal (>10kb) Multiome | 320 | |
| chr20:36,154,232–36,155,251 | 81.9 kb | Distal (>10kb) Multiome | 526 | |
| chr20:36,236,339–36,236,723 | at TSS | At TSS | 961 | |
| chr20:36,259,130–36,259,999 | 23.0 kb | Distal (>10kb) Multiome | 159 | |
| chr20:36,306,218–36,306,746 | 69.9 kb | Distal (>10kb) Multiome | 148 | |
| chr20:36,399,522–36,399,982 | 163.3 kb | Distal (>10kb) Multiome | 345 | |
| chr20:36,435,969–36,436,607 | 199.9 kb | Distal (>10kb) Multiome HiCAR | 268 | |
| chr20:36,460,578–36,462,746 | 224.8 kb | Distal (>10kb) Multiome | 955 |
Genomic view of the AAR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.