The gene is a member of the immunoglobulin superfamily. The encoded protein is associated with angiogenesis, with potential roles in endothelial tube formation and the migration of endothelial cells. It may also regulate smooth muscle cell migration via the RhoA pathway. The encoded protein can bind to heparin and may mediate heparin-sensitive cell adhesion. [provided by RefSeq, Oct 2014]
Transcription factors with Perturb-seq knockdown data for AAMP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = AAMP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of AAMP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:217,978,332–217,979,228 | 291.4 kb | Distal (>10kb) Multiome | 246 | |
| chr2:217,987,861–217,989,008 | 281.7 kb | Distal (>10kb) Multiome | 528 | |
| chr2:218,033,728–218,035,208 | 235.3 kb | Distal (>10kb) Multiome | 270 | |
| chr2:218,068,640–218,069,336 | 201.2 kb | Distal (>10kb) Multiome | 187 | |
| chr2:218,216,755–218,218,281 | 53.0 kb | Distal (>10kb) Multiome | 875 | |
| chr2:218,260,677–218,261,246 | 8.9 kb | Proximal (<10kb) | 103 | |
| chr2:218,269,385–218,270,929 | 173 bp | At TSS Multiome | 913 | |
| chr2:218,272,710–218,273,157 | 2.6 kb | Proximal (<10kb) | 500 | |
| chr2:218,290,037–218,290,611 | 20.1 kb | Distal (>10kb) Multiome | 264 | |
| chr2:218,291,910–218,292,722 | 22.4 kb | Distal (>10kb) Multiome | 695 | |
| chr2:218,322,154–218,324,454 | 53.0 kb | Distal (>10kb) Multiome | 914 | |
| chr2:218,367,421–218,368,194 | 97.7 kb | Distal (>10kb) Multiome | 450 | |
| chr2:218,387,091–218,388,220 | 117.8 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr2:218,395,568–218,397,399 | 126.1 kb | Distal (>10kb) Multiome HiCAR | 1048 | |
| chr2:218,397,484–218,401,433 | 127.8 kb | Distal (>10kb) Multiome HiCAR | 1114 | |
| chr2:218,405,424–218,407,478 | 136.3 kb | Distal (>10kb) Multiome | 1093 | |
| chr2:218,567,787–218,569,400 | 298.4 kb | Distal (>10kb) Multiome | 1083 |
Genomic view of the AAMP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.