Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZSCAN20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZSCAN20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZSCAN20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:33,180,551–33,182,306 | 291.8 kb | Distal (>10kb) Multiome | 692 | |
| chr1:33,255,428–33,256,795 | 217.0 kb | Distal (>10kb) Multiome | 509 | |
| chr1:33,338,430–33,338,960 | 134.0 kb | Distal (>10kb) Multiome | 254 | |
| chr1:33,342,108–33,342,803 | 130.2 kb | Distal (>10kb) Multiome | 722 | |
| chr1:33,349,195–33,350,690 | 122.7 kb | Distal (>10kb) Multiome | 874 | |
| chr1:33,363,845–33,364,278 | 108.6 kb | Distal (>10kb) Multiome | 214 | |
| chr1:33,430,392–33,431,511 | 41.6 kb | Distal (>10kb) Multiome | 555 | |
| chr1:33,470,591–33,470,753 | 1.9 kb | Proximal (<10kb) | 209 | |
| chr1:33,472,141–33,472,925 | 112 bp | At TSS Multiome | 656 |
Genomic view of the ZSCAN20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.