Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF823. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF823 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF823, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,481,847–11,483,040 | 256.2 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 233.5 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 209.8 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 202.7 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,539,738–11,540,434 | 198.8 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 179.6 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,597,206–11,598,107 | 141.4 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 99.1 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 43.9 kb | Distal (>10kb) Multiome | 608 | |
| chr19:11,737,998–11,739,422 | 133 bp | At TSS Multiome | 704 |
Genomic view of the ZNF823 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.