Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF805. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF805 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF805, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,191,186–57,191,993 | 49.2 kb | Distal (>10kb) Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 114 bp | At TSS Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 39.7 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 79.8 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 110.5 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 122.7 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 149.2 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 170.5 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 194.7 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 236.9 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 247.1 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 259.2 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 286.7 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the ZNF805 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.