This locus represents naturally occurring readthrough transcription between the neighboring ZNF8 (zinc finger protein 8) and ERVK3-1 (endogenous retrovirus group K3, member 1) genes on chromosome 19. The readthrough transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for ZNF8-ERVK3-1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF8-ERVK3-1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF8-ERVK3-1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:58,278,271–58,279,774 | at TSS | At TSS | 950 |
Genomic view of the ZNF8-ERVK3-1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.