Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF780A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF780A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF780A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,793,033–39,793,501 | 297.7 kb | Distal (>10kb) Multiome | 418 | |
| chr19:39,824,152–39,825,056 | 266.2 kb | Distal (>10kb) Multiome | 531 | |
| chr19:39,833,207–39,834,766 | 257.1 kb | Distal (>10kb) Multiome | 779 | |
| chr19:39,845,668–39,847,301 | 244.5 kb | Distal (>10kb) Multiome | 854 | |
| chr19:39,970,370–39,971,611 | 119.9 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,996,681–39,997,502 | 93.9 kb | Distal (>10kb) Multiome | 898 | |
| chr19:40,055,898–40,056,369 | 34.8 kb | Distal (>10kb) Multiome | 746 | |
| chr19:40,090,491–40,091,099 | 64 bp | At TSS Multiome | 831 | |
| chr19:40,190,883–40,192,408 | 101.0 kb | Distal (>10kb) Multiome | 764 | |
| chr19:40,217,060–40,217,642 | 126.4 kb | Distal (>10kb) Multiome | 366 | |
| chr19:40,284,527–40,285,917 | 194.5 kb | Distal (>10kb) Multiome | 913 | |
| chr19:40,347,917–40,348,964 | 257.6 kb | Distal (>10kb) Multiome | 843 | |
| chr19:40,365,649–40,366,111 | 274.9 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the ZNF780A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.