Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF77. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF77 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF77, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,702,249–2,703,088 | 242.2 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 223.8 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 204.9 kb | Distal (>10kb) Multiome | 1063 | |
| chr19:2,782,866–2,783,778 | 161.6 kb | Distal (>10kb) Multiome | 998 | |
| chr19:2,784,850–2,785,981 | 159.6 kb | Distal (>10kb) Multiome | 682 | |
| chr19:2,819,641–2,820,625 | 125.1 kb | Distal (>10kb) Multiome | 826 | |
| chr19:2,840,664–2,842,136 | 103.7 kb | Distal (>10kb) Multiome | 903 | |
| chr19:2,900,564–2,901,033 | 44.1 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 77 bp | At TSS Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 5.8 kb | Proximal (<10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 32.4 kb | Distal (>10kb) Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 39.1 kb | Distal (>10kb) Multiome | 523 | |
| chr19:3,024,668–3,025,742 | 80.2 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 90.8 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,045,731–3,048,029 | 102.1 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 117.6 kb | Distal (>10kb) Multiome | 369 | |
| chr19:3,093,786–3,095,227 | 149.2 kb | Distal (>10kb) Multiome | 515 | |
| chr19:3,095,637–3,096,163 | 151.0 kb | Distal (>10kb) Multiome | 256 | |
| chr19:3,185,437–3,186,577 | 240.8 kb | Distal (>10kb) Multiome | 751 | |
| chr19:3,224,482–3,224,897 | 279.7 kb | Distal (>10kb) Multiome | 253 |
Genomic view of the ZNF77 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.