Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF749. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF749 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF749, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:55,674,767–55,675,613 | 1760.2 kb | Distal (>10kb) Multiome HiCAR | 765 | |
| chr19:57,191,186–57,191,993 | 243.8 kb | Distal (>10kb) Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 194.8 kb | Distal (>10kb) Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 155.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 114.9 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 84.1 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 72.0 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 45.5 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 24.2 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 44 bp | At TSS Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 42.2 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 52.4 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 64.6 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 92.1 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 124.5 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 143.6 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 148.7 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 164.5 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 178.9 kb | Distal (>10kb) Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 197.8 kb | Distal (>10kb) Multiome | 652 | |
| chr19:57,681,556–57,682,393 | 246.6 kb | Distal (>10kb) Multiome | 724 | |
| chr19:57,708,682–57,709,450 | 273.9 kb | Distal (>10kb) Multiome | 199 | |
| chr19:57,727,326–57,727,941 | 292.3 kb | Distal (>10kb) Multiome | 400 | |
| chr19:58,182,544–58,183,906 | 747.9 kb | Distal (>10kb) Multiome HiCAR | 1019 |
Genomic view of the ZNF749 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.