Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF74. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF74 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF74, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,116,628–20,118,048 | 276.8 kb | Distal (>10kb) Multiome | 999 | |
| chr22:20,130,806–20,131,896 | 262.9 kb | Distal (>10kb) Multiome | 525 | |
| chr22:20,203,393–20,204,086 | 190.3 kb | Distal (>10kb) Multiome | 292 | |
| chr22:20,243,636–20,244,300 | 150.1 kb | Distal (>10kb) Multiome | 251 | |
| chr22:20,267,373–20,268,700 | 125.7 kb | Distal (>10kb) Multiome | 449 | |
| chr22:20,298,366–20,300,076 | 94.9 kb | Distal (>10kb) Multiome | 538 | |
| chr22:20,319,527–20,320,815 | 74.0 kb | Distal (>10kb) Multiome | 805 | |
| chr22:20,393,744–20,394,682 | at TSS | At TSS Multiome | 854 | |
| chr22:20,418,190–20,418,662 | 24.3 kb | Distal (>10kb) Multiome | 594 | |
| chr22:20,431,567–20,432,135 | 37.7 kb | Distal (>10kb) Multiome | 135 | |
| chr22:20,437,361–20,438,451 | 43.8 kb | Distal (>10kb) Multiome | 393 | |
| chr22:20,495,029–20,496,932 | 101.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr22:20,507,376–20,507,935 | 113.5 kb | Distal (>10kb) Multiome | 894 | |
| chr22:20,606,015–20,606,540 | 212.3 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the ZNF74 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.