This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for ZNF630. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF630 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF630, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:47,836,213–47,837,023 | 235.0 kb | Distal (>10kb) Multiome | 544 | |
| chrX:48,021,260–48,021,892 | 50.1 kb | Distal (>10kb) Multiome | 345 | |
| chrX:48,071,368–48,072,042 | 115 bp | At TSS Multiome | 269 | |
| chrX:48,475,845–48,476,469 | 404.5 kb | Distal (>10kb) Multiome HiCAR | 613 | |
| chrX:48,508,766–48,509,247 | 437.3 kb | Distal (>10kb) Multiome HiCAR | 400 |
Genomic view of the ZNF630 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.