Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF594. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF594 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF594, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,898,962–4,900,112 | 292.4 kb | Distal (>10kb) Multiome | 257 | |
| chr17:4,900,249–4,901,057 | 291.1 kb | Distal (>10kb) Multiome | 145 | |
| chr17:4,909,117–4,909,538 | 282.6 kb | Distal (>10kb) Multiome | 553 | |
| chr17:4,939,475–4,941,034 | 251.7 kb | Distal (>10kb) Multiome | 821 | |
| chr17:4,947,426–4,950,636 | 241.7 kb | Distal (>10kb) Multiome | 1080 | |
| chr17:4,966,739–4,968,875 | 224.3 kb | Distal (>10kb) Multiome | 982 | |
| chr17:4,986,950–4,987,983 | 204.3 kb | Distal (>10kb) Multiome | 881 | |
| chr17:4,996,838–4,998,964 | 194.1 kb | Distal (>10kb) Multiome | 759 | |
| chr17:5,031,487–5,032,081 | 160.2 kb | Distal (>10kb) Multiome | 342 | |
| chr17:5,111,339–5,112,612 | 79.9 kb | Distal (>10kb) Multiome | 864 | |
| chr17:5,191,578–5,192,305 | 64 bp | At TSS Multiome | 771 | |
| chr17:5,281,614–5,283,116 | 90.4 kb | Distal (>10kb) Multiome | 705 | |
| chr17:5,419,157–5,420,471 | 228.0 kb | Distal (>10kb) Multiome | 891 | |
| chr17:5,438,801–5,439,554 | 247.3 kb | Distal (>10kb) Multiome | 889 | |
| chr17:5,468,372–5,469,379 | 277.1 kb | Distal (>10kb) Multiome | 890 | |
| chr17:5,485,725–5,487,042 | 294.6 kb | Distal (>10kb) Multiome | 951 |
Genomic view of the ZNF594 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.