Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF570. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF570 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF570, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:37,217,536–37,218,551 | 251.3 kb | Distal (>10kb) Multiome | 914 | |
| chr19:37,370,849–37,371,460 | 98.3 kb | Distal (>10kb) Multiome | 857 | |
| chr19:37,466,731–37,467,830 | 2.0 kb | Proximal (<10kb) Multiome | 842 | |
| chr19:37,468,785–37,469,861 | 44 bp | At TSS Multiome | 756 | |
| chr19:37,506,082–37,507,237 | 37.5 kb | Distal (>10kb) Multiome | 467 | |
| chr19:37,594,052–37,595,363 | 125.3 kb | Distal (>10kb) Multiome | 835 | |
| chr19:37,654,736–37,656,463 | 186.4 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:37,691,873–37,692,535 | 222.9 kb | Distal (>10kb) Multiome | 609 | |
| chr19:37,719,078–37,720,106 | 250.4 kb | Distal (>10kb) Multiome | 698 |
Genomic view of the ZNF570 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.