Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF546. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF546 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF546, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:39,793,033–39,793,501 | 203.8 kb | Distal (>10kb) Multiome | 418 | |
| chr19:39,824,152–39,825,056 | 172.4 kb | Distal (>10kb) Multiome | 531 | |
| chr19:39,833,207–39,834,766 | 163.2 kb | Distal (>10kb) Multiome | 779 | |
| chr19:39,845,668–39,847,301 | 150.7 kb | Distal (>10kb) Multiome | 854 | |
| chr19:39,970,370–39,971,611 | 26.0 kb | Distal (>10kb) Multiome | 930 | |
| chr19:39,996,681–39,997,502 | 14 bp | At TSS Multiome | 898 | |
| chr19:40,055,898–40,056,369 | 59.1 kb | Distal (>10kb) Multiome | 746 | |
| chr19:40,090,491–40,091,099 | 93.8 kb | Distal (>10kb) Multiome | 831 | |
| chr19:40,190,883–40,192,408 | 194.8 kb | Distal (>10kb) Multiome | 764 | |
| chr19:40,217,060–40,217,642 | 220.2 kb | Distal (>10kb) Multiome | 366 | |
| chr19:40,284,527–40,285,917 | 288.3 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the ZNF546 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.