The protein encoded by this gene is a highly conserved zinc finger protein. The encoded protein is most abundant in brain, where it negatively regulates neuronal differentiation. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for ZNF536. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF536 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF536, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:30,219,344–30,219,753 | 8.2 kb | Proximal (<10kb) | 38 | |
| chr19:30,222,321–30,222,899 | 5.1 kb | Proximal (<10kb) | 172 | |
| chr19:30,227,277–30,228,219 | at TSS | At TSS | 361 | |
| chr19:30,228,453–30,228,589 | 501 bp | At TSS | 131 | |
| chr19:30,228,695–30,229,107 | 743 bp | At TSS | 158 |
Genomic view of the ZNF536 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.