Transcription factors with Perturb-seq knockdown data for ZNF503-AS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF503-AS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF503-AS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:75,395,145–75,397,482 | 5.4 kb | Proximal (<10kb) | 341 | |
| chr10:75,398,678–75,400,431 | 2.5 kb | Proximal (<10kb) | 501 | |
| chr10:75,400,704–75,404,045 | at TSS | At TSS | 978 | |
| chr10:75,404,151–75,405,735 | 1.3 kb | Proximal (<10kb) | 760 | |
| chr10:75,407,388–75,408,379 | 4.5 kb | Proximal (<10kb) | 245 | |
| chr10:75,408,722–75,408,870 | 5.8 kb | Proximal (<10kb) | 141 | |
| chr10:75,408,986–75,410,039 | 6.1 kb | Proximal (<10kb) | 639 |
Genomic view of the ZNF503-AS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.