This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for ZNF473. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF473 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF473, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:49,746,188–49,746,748 | 279.6 kb | Distal (>10kb) Multiome | 283 | |
| chr19:49,766,231–49,767,440 | 259.3 kb | Distal (>10kb) Multiome | 718 | |
| chr19:49,802,146–49,802,787 | 223.6 kb | Distal (>10kb) Multiome | 200 | |
| chr19:49,805,226–49,805,871 | 220.5 kb | Distal (>10kb) Multiome | 245 | |
| chr19:49,808,201–49,809,746 | 217.1 kb | Distal (>10kb) Multiome | 509 | |
| chr19:49,812,926–49,813,834 | 212.6 kb | Distal (>10kb) Multiome | 650 | |
| chr19:49,817,356–49,818,721 | 207.8 kb | Distal (>10kb) Multiome | 784 | |
| chr19:49,850,394–49,852,067 | 175.1 kb | Distal (>10kb) Multiome | 862 | |
| chr19:49,866,817–49,868,124 | 158.7 kb | Distal (>10kb) Multiome | 874 | |
| chr19:49,869,068–49,870,398 | 156.4 kb | Distal (>10kb) Multiome | 832 | |
| chr19:49,875,842–49,878,576 | 148.3 kb | Distal (>10kb) Multiome | 1153 | |
| chr19:49,889,853–49,891,381 | 135.5 kb | Distal (>10kb) Multiome | 640 | |
| chr19:49,928,884–49,930,473 | 96.1 kb | Distal (>10kb) Multiome | 1141 | |
| chr19:49,987,157–49,987,669 | 38.7 kb | Distal (>10kb) Multiome | 1095 | |
| chr19:50,024,875–50,026,285 | 363 bp | At TSS Multiome | 1137 | |
| chr19:50,147,523–50,148,432 | 122.1 kb | Distal (>10kb) Multiome | 615 | |
| chr19:50,203,034–50,204,072 | 177.5 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,205,195–50,205,903 | 179.4 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,311,942–50,312,908 | 286.2 kb | Distal (>10kb) Multiome | 364 | |
| chr19:50,313,900–50,314,529 | 288.2 kb | Distal (>10kb) Multiome | 114 | |
| chr19:50,315,313–50,316,408 | 290.0 kb | Distal (>10kb) Multiome | 363 | |
| chr19:50,325,322–50,326,594 | 299.8 kb | Distal (>10kb) Multiome | 748 |
Genomic view of the ZNF473 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.