Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF461. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF461 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF461, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:36,378,606–36,379,573 | 287.7 kb | Distal (>10kb) Multiome | 839 | |
| chr19:36,418,146–36,419,031 | 248.2 kb | Distal (>10kb) Multiome | 638 | |
| chr19:36,488,856–36,490,274 | 177.2 kb | Distal (>10kb) Multiome | 991 | |
| chr19:36,527,962–36,529,500 | 138.3 kb | Distal (>10kb) Multiome | 937 | |
| chr19:36,572,622–36,573,936 | 93.5 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:36,604,710–36,605,744 | 61.5 kb | Distal (>10kb) Multiome | 657 | |
| chr19:36,666,500–36,667,489 | 11 bp | At TSS Multiome | 842 | |
| chr19:36,686,842–36,688,044 | 20.7 kb | Distal (>10kb) Multiome | 876 | |
| chr19:36,771,571–36,773,224 | 104.9 kb | Distal (>10kb) Multiome | 721 | |
| chr19:36,837,900–36,839,014 | 171.6 kb | Distal (>10kb) Multiome | 855 | |
| chr19:36,849,748–36,851,333 | 183.5 kb | Distal (>10kb) Multiome | 755 | |
| chr19:36,915,949–36,916,617 | 249.4 kb | Distal (>10kb) Multiome | 584 |
Genomic view of the ZNF461 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.