Transcription factors with Perturb-seq knockdown data for ZNF460-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF460-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF460-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,191,186–57,191,993 | 88.8 kb | Distal (>10kb) Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 39.8 kb | Distal (>10kb) Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 13 bp | At TSS Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 40.1 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 70.9 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 83.1 kb | Distal (>10kb) Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 109.5 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 130.8 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 155.1 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 197.2 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 207.4 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 219.6 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 247.1 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 279.5 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 298.6 kb | Distal (>10kb) Multiome | 668 |
Genomic view of the ZNF460-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.