ZNF446

zinc finger protein 446 | FLJ20626, ZKSCAN20, ZSCAN52

Enables identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 12 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)chromatin (GO:0000785)extracellular region (GO:0005576)identical protein binding (GO:0042802)nuclear speck (GO:0016607)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating ZNF446 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF446. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF446 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF446

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF446, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:58,182,544–58,183,906	292.9 kb	Distal (>10kb) Multiome	1019
chr19:58,228,362–58,229,199	247.3 kb	Distal (>10kb) Multiome	706
chr19:58,278,271–58,279,774	197.3 kb	Distal (>10kb) Multiome	950
chr19:58,304,887–58,305,868	170.8 kb	Distal (>10kb) Multiome	858
chr19:58,326,789–58,327,710	149.1 kb	Distal (>10kb) Multiome	985
chr19:58,347,086–58,347,987	128.5 kb	Distal (>10kb) Multiome	467
chr19:58,356,174–58,356,775	119.6 kb	Distal (>10kb) Multiome	101
chr19:58,361,859–58,363,243	113.4 kb	Distal (>10kb) Multiome	972
chr19:58,380,269–58,381,636	95.1 kb	Distal (>10kb) Multiome	1044
chr19:58,386,311–58,387,531	89.0 kb	Distal (>10kb) Multiome	1010
chr19:58,400,803–58,401,800	74.8 kb	Distal (>10kb) Multiome	728
chr19:58,408,032–58,409,025	67.6 kb	Distal (>10kb) Multiome	854
chr19:58,451,175–58,452,075	24.6 kb	Distal (>10kb) Multiome	702
chr19:58,466,585–58,467,517	9.2 kb	Proximal (<10kb) Multiome	701
chr19:58,475,442–58,476,812	150 bp	At TSS Multiome	934
chr19:58,498,641–58,499,856	23.3 kb	Distal (>10kb) Multiome	939
chr19:58,513,642–58,514,431	38.0 kb	Distal (>10kb) Multiome	706
chr19:58,518,851–58,520,372	43.6 kb	Distal (>10kb) Multiome	1175
chr19:58,538,071–58,538,713	62.4 kb	Distal (>10kb) Multiome	386

Genome Browser

Genomic view of the ZNF446 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.