Transcription factors with Perturb-seq knockdown data for ZNF407-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF407-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF407-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:74,495,562–74,497,259 | 102.4 kb | Distal (>10kb) Multiome | 913 | |
| chr18:74,507,531–74,509,605 | 89.6 kb | Distal (>10kb) Multiome | 369 | |
| chr18:74,562,032–74,563,296 | 36.1 kb | Distal (>10kb) Multiome | 144 | |
| chr18:74,597,119–74,599,116 | 589 bp | At TSS Multiome | 919 | |
| chr18:74,805,673–74,806,906 | 207.7 kb | Distal (>10kb) Multiome | 267 | |
| chr18:74,819,422–74,820,438 | 221.3 kb | Distal (>10kb) Multiome | 234 |
Genomic view of the ZNF407-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.