Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF333. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF333 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF333, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:14,405,442–14,406,893 | 283.9 kb | Distal (>10kb) Multiome | 662 | |
| chr19:14,418,847–14,419,795 | 270.6 kb | Distal (>10kb) Multiome | 817 | |
| chr19:14,432,848–14,433,780 | 256.7 kb | Distal (>10kb) Multiome | 524 | |
| chr19:14,450,232–14,451,000 | 239.4 kb | Distal (>10kb) Multiome | 271 | |
| chr19:14,472,177–14,472,986 | 217.5 kb | Distal (>10kb) Multiome | 566 | |
| chr19:14,495,705–14,496,690 | 193.8 kb | Distal (>10kb) Multiome | 813 | |
| chr19:14,517,523–14,519,160 | 171.5 kb | Distal (>10kb) Multiome | 952 | |
| chr19:14,528,857–14,530,279 | 160.6 kb | Distal (>10kb) Multiome | 842 | |
| chr19:14,536,700–14,537,683 | 152.9 kb | Distal (>10kb) Multiome | 329 | |
| chr19:14,556,545–14,557,088 | 133.2 kb | Distal (>10kb) Multiome | 509 | |
| chr19:14,564,060–14,565,155 | 125.6 kb | Distal (>10kb) Multiome | 226 | |
| chr19:14,571,772–14,572,330 | 118.0 kb | Distal (>10kb) Multiome | 896 | |
| chr19:14,689,407–14,690,497 | 110 bp | At TSS Multiome | 624 | |
| chr19:14,979,199–14,980,219 | 289.7 kb | Distal (>10kb) Multiome | 147 | |
| chr19:16,075,837–16,077,586 | 1386.3 kb | Distal (>10kb) Multiome HiCAR | 735 |
Genomic view of the ZNF333 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.