This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for ZNF275. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF275 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF275, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:152,941,291–152,942,073 | 392.4 kb | Distal (>10kb) Multiome HiCAR | 549 | |
| chrX:153,226,172–153,227,033 | 107.6 kb | Distal (>10kb) Multiome | 178 | |
| chrX:153,333,932–153,334,640 | 22 bp | At TSS Multiome | 433 | |
| chrX:153,469,901–153,471,108 | 136.6 kb | Distal (>10kb) Multiome | 508 | |
| chrX:153,598,511–153,599,722 | 265.1 kb | Distal (>10kb) Multiome | 459 | |
| chrX:153,609,905–153,610,354 | 275.9 kb | Distal (>10kb) Multiome | 404 |
Genomic view of the ZNF275 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.