Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,535,847–11,536,353 | 604.2 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr19:11,539,738–11,540,434 | 600.3 kb | Distal (>10kb) Multiome HiCAR | 176 | |
| chr19:11,558,908–11,559,777 | 581.1 kb | Distal (>10kb) Multiome HiCAR | 686 | |
| chr19:11,597,206–11,598,107 | 542.9 kb | Distal (>10kb) Multiome HiCAR | 914 | |
| chr19:11,639,337–11,640,481 | 500.6 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr19:12,139,827–12,140,825 | 62 bp | At TSS Multiome | 594 | |
| chr19:12,141,030–12,141,437 | 680 bp | At TSS | 392 | |
| chr19:12,156,210–12,156,965 | 16.4 kb | Distal (>10kb) Multiome | 638 | |
| chr19:12,162,692–12,163,608 | 22.7 kb | Distal (>10kb) Multiome | 697 | |
| chr19:12,365,585–12,366,054 | 225.4 kb | Distal (>10kb) Multiome | 577 | |
| chr19:12,400,090–12,401,657 | 260.9 kb | Distal (>10kb) Multiome | 671 |
Genomic view of the ZNF20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.