This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ZNF165. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF165 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF165, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:27,791,232–27,791,741 | 289.1 kb | Distal (>10kb) Multiome | 564 | |
| chr6:27,806,645–27,808,975 | 272.5 kb | Distal (>10kb) Multiome | 963 | |
| chr6:27,809,816–27,810,576 | 270.5 kb | Distal (>10kb) Multiome | 914 | |
| chr6:27,813,688–27,816,146 | 265.6 kb | Distal (>10kb) Multiome | 564 | |
| chr6:27,836,792–27,839,128 | 242.1 kb | Distal (>10kb) Multiome | 1131 | |
| chr6:27,865,093–27,868,152 | 212.9 kb | Distal (>10kb) Multiome | 744 | |
| chr6:27,870,957–27,872,527 | 208.3 kb | Distal (>10kb) Multiome | 426 | |
| chr6:27,872,808–27,873,995 | 207.0 kb | Distal (>10kb) Multiome | 372 | |
| chr6:27,889,436–27,895,972 | 189.7 kb | Distal (>10kb) Multiome | 1215 | |
| chr6:27,902,800–27,903,766 | 177.6 kb | Distal (>10kb) Multiome | 891 | |
| chr6:28,079,998–28,081,441 | 372 bp | At TSS Multiome | 1054 | |
| chr6:28,104,510–28,105,291 | 24.3 kb | Distal (>10kb) Multiome | 927 | |
| chr6:28,136,684–28,137,470 | 56.5 kb | Distal (>10kb) Multiome | 1035 | |
| chr6:28,141,479–28,142,195 | 61.3 kb | Distal (>10kb) Multiome | 1010 | |
| chr6:28,225,159–28,225,667 | 144.8 kb | Distal (>10kb) Multiome | 914 | |
| chr6:28,281,346–28,282,033 | 201.0 kb | Distal (>10kb) Multiome | 751 | |
| chr6:28,335,073–28,336,704 | 255.2 kb | Distal (>10kb) Multiome | 1036 | |
| chr6:28,349,817–28,350,289 | 269.5 kb | Distal (>10kb) Multiome | 884 | |
| chr6:28,356,177–28,356,613 | 275.8 kb | Distal (>10kb) Multiome | 569 |
Genomic view of the ZNF165 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.