Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFYVE28. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFYVE28 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFYVE28, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:2,241,509–2,242,666 | 176.4 kb | Distal (>10kb) Multiome | 783 | |
| chr4:2,261,141–2,263,069 | 156.3 kb | Distal (>10kb) Multiome | 806 | |
| chr4:2,401,939–2,402,479 | 16.4 kb | Distal (>10kb) Multiome | 317 | |
| chr4:2,413,008–2,413,630 | 5.3 kb | Proximal (<10kb) Multiome | 564 | |
| chr4:2,416,537–2,417,784 | 866 bp | At TSS | 300 | |
| chr4:2,417,912–2,419,213 | 165 bp | At TSS Multiome | 628 | |
| chr4:2,462,245–2,463,183 | 44.1 kb | Distal (>10kb) Multiome | 643 | |
| chr4:2,468,399–2,469,652 | 50.3 kb | Distal (>10kb) Multiome | 858 | |
| chr4:2,535,307–2,537,785 | 117.8 kb | Distal (>10kb) Multiome | 860 |
Genomic view of the ZFYVE28 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.