This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for ZFYVE27. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFYVE27 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFYVE27, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,445,521–97,446,585 | 291.0 kb | Distal (>10kb) Multiome | 802 | |
| chr10:97,497,718–97,499,773 | 238.5 kb | Distal (>10kb) Multiome | 967 | |
| chr10:97,553,598–97,554,047 | 183.4 kb | Distal (>10kb) Multiome | 340 | |
| chr10:97,632,775–97,633,915 | 103.7 kb | Distal (>10kb) Multiome | 725 | |
| chr10:97,640,236–97,641,335 | 96.6 kb | Distal (>10kb) Multiome | 712 | |
| chr10:97,686,724–97,687,987 | 49.8 kb | Distal (>10kb) Multiome HiCAR | 993 | |
| chr10:97,713,223–97,715,263 | 23.4 kb | Distal (>10kb) Multiome | 639 | |
| chr10:97,731,841–97,732,057 | 5.1 kb | Proximal (<10kb) | 197 | |
| chr10:97,736,595–97,737,824 | 72 bp | At TSS Multiome | 1009 | |
| chr10:97,771,123–97,772,389 | 34.6 kb | Distal (>10kb) Multiome | 356 | |
| chr10:97,788,725–97,789,448 | 52.0 kb | Distal (>10kb) Multiome | 398 | |
| chr10:97,849,566–97,850,474 | 112.9 kb | Distal (>10kb) Multiome | 400 | |
| chr10:97,857,830–97,858,402 | 120.9 kb | Distal (>10kb) Multiome | 160 | |
| chr10:97,869,190–97,869,924 | 132.4 kb | Distal (>10kb) Multiome HiCAR | 506 | |
| chr10:98,029,703–98,031,553 | 293.6 kb | Distal (>10kb) Multiome | 325 |
Genomic view of the ZFYVE27 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.