Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of lipid metabolic process and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFP69. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFP69 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFP69, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:40,257,418–40,258,681 | 219.2 kb | Distal (>10kb) Multiome | 1088 | |
| chr1:40,315,144–40,317,664 | 161.8 kb | Distal (>10kb) Multiome | 729 | |
| chr1:40,373,298–40,374,444 | 103.6 kb | Distal (>10kb) Multiome | 747 | |
| chr1:40,394,885–40,396,067 | 81.6 kb | Distal (>10kb) Multiome | 153 | |
| chr1:40,449,758–40,450,645 | 27.2 kb | Distal (>10kb) Multiome | 807 | |
| chr1:40,476,972–40,477,791 | 37 bp | At TSS Multiome | 683 | |
| chr1:40,508,401–40,509,160 | 31.5 kb | Distal (>10kb) Multiome | 805 | |
| chr1:40,531,425–40,532,089 | 54.3 kb | Distal (>10kb) Multiome | 724 | |
| chr1:40,665,223–40,666,079 | 188.4 kb | Distal (>10kb) Multiome | 465 | |
| chr1:40,691,236–40,692,758 | 214.6 kb | Distal (>10kb) Multiome | 1088 | |
| chr1:40,708,827–40,709,450 | 231.9 kb | Distal (>10kb) Multiome | 526 |
Genomic view of the ZFP69 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.