Predicted to enable DNA binding activity and zinc ion binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZFAND3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZFAND3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZFAND3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:37,565,348–37,566,769 | 254.1 kb | Distal (>10kb) Multiome | 518 | |
| chr6:37,647,989–37,649,458 | 171.2 kb | Distal (>10kb) Multiome | 333 | |
| chr6:37,697,011–37,698,118 | 122.1 kb | Distal (>10kb) Multiome | 456 | |
| chr6:37,705,006–37,706,173 | 114.3 kb | Distal (>10kb) Multiome | 470 | |
| chr6:37,783,408–37,784,237 | 36.1 kb | Distal (>10kb) Multiome | 161 | |
| chr6:37,791,133–37,791,889 | 28.4 kb | Distal (>10kb) Multiome | 735 | |
| chr6:37,818,611–37,820,547 | 524 bp | At TSS Multiome | 1029 | |
| chr6:37,822,808–37,823,024 | 3.0 kb | Proximal (<10kb) | 104 |
Genomic view of the ZFAND3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.