ZDHHC8

zDHHC palmitoyltransferase 8 | DHHC8, KIAA1292, ZNF378

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

Biological processes 22 terms

Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)cytosol (GO:0005829)glutamatergic synapse (GO:0098978)high-density lipoprotein particle assembly (GO:0034380)host-mediated activation of viral process (GO:0044794)mitochondrial membrane (GO:0031966)mitochondrion (GO:0005739)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)peptidyl-L-cysteine S-palmitoylation (GO:0018230)positive regulation of cholesterol efflux (GO:0010875)positive regulation of cholesterol efflux (GO:0010875)positive regulation of protein localization to plasma membrane (GO:1903078)postsynapse (GO:0098794)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)regulation of postsynapse assembly (GO:0150052)

Expression (TPM)

TFs regulating ZDHHC8 0 TFs

Transcription factors with Perturb-seq knockdown data for ZDHHC8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZDHHC8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:19,854,381–19,855,705	276.9 kb	Distal (>10kb) Multiome	1014
chr22:19,891,576–19,892,031	240.1 kb	Distal (>10kb) Multiome	631
chr22:19,959,058–19,959,828	172.3 kb	Distal (>10kb) Multiome	576
chr22:19,962,339–19,962,798	169.3 kb	Distal (>10kb) Multiome	442
chr22:19,986,350–19,987,426	144.6 kb	Distal (>10kb) Multiome	539
chr22:20,016,068–20,017,437	115.0 kb	Distal (>10kb) Multiome	640
chr22:20,020,662–20,021,745	110.8 kb	Distal (>10kb) Multiome	718
chr22:20,079,663–20,080,743	51.7 kb	Distal (>10kb) Multiome	994
chr22:20,116,628–20,118,048	14.5 kb	Distal (>10kb) Multiome	999
chr22:20,130,806–20,131,896	573 bp	At TSS Multiome	525
chr22:20,203,393–20,204,086	72.0 kb	Distal (>10kb) Multiome	292
chr22:20,243,636–20,244,300	112.2 kb	Distal (>10kb) Multiome	251
chr22:20,267,373–20,268,700	136.6 kb	Distal (>10kb) Multiome	449
chr22:20,298,366–20,300,076	167.4 kb	Distal (>10kb) Multiome	538
chr22:20,319,527–20,320,815	188.3 kb	Distal (>10kb) Multiome	805
chr22:20,393,744–20,394,682	262.3 kb	Distal (>10kb) Multiome	854
chr22:20,418,190–20,418,662	286.6 kb	Distal (>10kb) Multiome	594
chr22:20,431,567–20,432,135	300.0 kb	Distal (>10kb) Multiome	135

Genome Browser

Genomic view of the ZDHHC8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.