Enables palmitoyltransferase activity and protein-cysteine S-stearoyltransferase activity. Involved in positive regulation of mitochondrial fusion; protein palmitoylation; and protein stearoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:112,183,224–112,184,131 | 263.2 kb | Distal (>10kb) Multiome | 766 | |
| chr10:112,307,523–112,308,556 | 139.0 kb | Distal (>10kb) Multiome | 369 | |
| chr10:112,446,658–112,447,668 | 110 bp | At TSS Multiome | 826 |
Genomic view of the ZDHHC6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.