Enables protein-cysteine S-palmitoyltransferase activity. Involved in negative regulation of cGAS/STING signaling pathway; negative regulation of innate immune response; and peptidyl-L-cysteine S-palmitoylation. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZDHHC18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,529,200–26,531,855 | 295.3 kb | Distal (>10kb) Multiome | 703 | |
| chr1:26,620,089–26,621,718 | 206.0 kb | Distal (>10kb) Multiome | 1174 | |
| chr1:26,692,203–26,693,499 | 134.2 kb | Distal (>10kb) Multiome | 974 | |
| chr1:26,695,271–26,696,473 | 131.0 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:26,723,135–26,723,892 | 103.1 kb | Distal (>10kb) Multiome | 671 | |
| chr1:26,786,686–26,788,664 | 38.7 kb | Distal (>10kb) Multiome | 918 | |
| chr1:26,826,166–26,827,148 | 14 bp | At TSS Multiome | 510 | |
| chr1:26,862,775–26,863,565 | 36.3 kb | Distal (>10kb) Multiome | 486 | |
| chr1:26,864,355–26,865,945 | 38.5 kb | Distal (>10kb) Multiome | 892 | |
| chr1:26,889,797–26,890,628 | 63.6 kb | Distal (>10kb) Multiome | 906 | |
| chr1:26,899,986–26,900,610 | 73.7 kb | Distal (>10kb) Multiome | 792 | |
| chr1:26,913,478–26,914,582 | 87.6 kb | Distal (>10kb) Multiome | 877 | |
| chr1:26,921,268–26,922,160 | 95.0 kb | Distal (>10kb) Multiome | 838 | |
| chr1:26,959,908–26,960,855 | 133.8 kb | Distal (>10kb) Multiome | 607 | |
| chr1:26,992,986–26,995,593 | 166.9 kb | Distal (>10kb) Multiome | 854 | |
| chr1:26,997,489–26,998,161 | 171.2 kb | Distal (>10kb) Multiome | 550 | |
| chr1:27,010,686–27,011,820 | 184.5 kb | Distal (>10kb) Multiome | 379 | |
| chr1:27,012,151–27,013,639 | 186.3 kb | Distal (>10kb) Multiome | 712 | |
| chr1:27,031,351–27,031,956 | 205.0 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,102,589–27,103,140 | 276.2 kb | Distal (>10kb) Multiome | 263 |
Genomic view of the ZDHHC18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.