ZDHHC12
zDHHC palmitoyltransferase 12 | FLJ14524, ZNF400

Enables protein-cysteine S-palmitoyltransferase activity. Involved in gephyrin clustering involved in postsynaptic density assembly; negative regulation of NLRP3 inflammasome complex assembly; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum. Is active in dendritic spine. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1
Biological processes 23 terms
Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi apparatus (GO:0005794)Golgi membrane (GO:0000139)Golgi membrane (GO:0000139)dendritic spine (GO:0043197)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)endoplasmic reticulum membrane (GO:0005789)gephyrin clustering involved in postsynaptic density assembly (GO:0097116)gephyrin clustering involved in postsynaptic density assembly (GO:0097116)gephyrin clustering involved in postsynaptic density assembly (GO:0097116)negative regulation of NLRP3 inflammasome complex assembly (GO:1900226)palmitoyltransferase activity (GO:0016409)palmitoyltransferase activity (GO:0016409)peptidyl-L-cysteine S-palmitoylation (GO:0018230)positive regulation of synaptic transmission, GABAergic (GO:0032230)positive regulation of synaptic transmission, GABAergic (GO:0032230)protein binding (GO:0005515)protein targeting to membrane (GO:0006612)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)protein-cysteine S-palmitoyltransferase activity (GO:0019706)
Expression (TPM)
ZDHHC12 — as a Regulated Gene

TFs regulating ZDHHC12 0 TFs

Transcription factors with Perturb-seq knockdown data for ZDHHC12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZDHHC12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to ZDHHC12

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZDHHC12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr9:128,455,721–128,456,522 268.0 kb Distal (>10kb) Multiome 684
chr9:128,504,482–128,505,188 219.4 kb Distal (>10kb) Multiome 766
chr9:128,552,006–128,553,125 171.6 kb Distal (>10kb) Multiome 839
chr9:128,656,436–128,657,126 67.3 kb Distal (>10kb) Multiome 1009
chr9:128,683,393–128,684,010 40.5 kb Distal (>10kb) Multiome 296
chr9:128,684,170–128,684,813 39.4 kb Distal (>10kb) Multiome 574
chr9:128,688,449–128,689,713 35.0 kb Distal (>10kb) Multiome 805
chr9:128,702,246–128,702,946 21.5 kb Distal (>10kb) Multiome 720
chr9:128,723,691–128,725,229 125 bp At TSS Multiome 821
chr9:128,733,276–128,733,613 9.2 kb Proximal (<10kb) 496
chr9:128,771,658–128,772,301 47.9 kb Distal (>10kb) Multiome 940
chr9:128,786,928–128,787,516 63.1 kb Distal (>10kb) Multiome 1040
chr9:128,818,208–128,819,406 94.3 kb Distal (>10kb) Multiome 839
chr9:128,829,505–128,830,189 105.7 kb Distal (>10kb) Multiome 782
chr9:128,881,863–128,882,454 158.0 kb Distal (>10kb) Multiome 777
chr9:128,921,941–128,922,727 198.2 kb Distal (>10kb) Multiome 378
chr9:128,947,329–128,947,815 223.5 kb Distal (>10kb) Multiome 865

Genome Browser

Genomic view of the ZDHHC12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr9:128,445,721 – 128,957,815
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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