Enables RNA binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:81,232,714–81,233,670 | 68.2 kb | Distal (>10kb) Multiome | 329 | |
| chr5:81,269,902–81,270,952 | 31.1 kb | Distal (>10kb) Multiome | 126 | |
| chr5:81,299,612–81,299,825 | 1.8 kb | Proximal (<10kb) | 133 | |
| chr5:81,301,217–81,302,258 | 66 bp | At TSS Multiome | 872 | |
| chr5:81,393,587–81,394,731 | 92.6 kb | Distal (>10kb) Multiome | 292 | |
| chr5:81,407,752–81,408,374 | 106.5 kb | Distal (>10kb) Multiome | 76 |
Genomic view of the ZCCHC9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.