Enables double-stranded DNA binding activity. Involved in cellular response to exogenous dsRNA; detection of virus; and positive regulation of innate immune response. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZCCHC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZCCHC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZCCHC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:266,689–267,291 | 30.5 kb | Distal (>10kb) Multiome | 931 | |
| chr20:290,009–290,864 | 7.0 kb | Proximal (<10kb) Multiome | 706 | |
| chr20:295,883–296,330 | 1.2 kb | Proximal (<10kb) | 27 | |
| chr20:297,159–298,781 | 105 bp | At TSS Multiome | 1084 | |
| chr20:300,328–300,910 | 2.8 kb | Proximal (<10kb) | 166 | |
| chr20:300,984–301,434 | 3.7 kb | Proximal (<10kb) Multiome | 252 | |
| chr20:309,597–310,812 | 12.9 kb | Distal (>10kb) Multiome | 589 | |
| chr20:323,634–328,069 | 29.7 kb | Distal (>10kb) Multiome | 1260 | |
| chr20:330,299–330,873 | 33.1 kb | Distal (>10kb) Multiome | 376 | |
| chr20:346,592–348,332 | 50.3 kb | Distal (>10kb) Multiome | 1061 | |
| chr20:354,335–354,944 | 57.1 kb | Distal (>10kb) Multiome | 631 | |
| chr20:380,569–381,493 | 83.3 kb | Distal (>10kb) Multiome | 958 | |
| chr20:381,625–382,263 | 84.5 kb | Distal (>10kb) Multiome | 745 | |
| chr20:407,136–409,109 | 110.5 kb | Distal (>10kb) Multiome | 1064 | |
| chr20:461,861–463,102 | 165.0 kb | Distal (>10kb) Multiome | 871 | |
| chr20:543,069–544,398 | 246.3 kb | Distal (>10kb) Multiome | 965 | |
| chr20:555,914–556,523 | 258.6 kb | Distal (>10kb) Multiome | 249 | |
| chr20:574,398–574,909 | 277.1 kb | Distal (>10kb) Multiome | 119 |
Genomic view of the ZCCHC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.