Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZC3HAV1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3HAV1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3HAV1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:138,980,951–138,982,350 | 54.5 kb | Distal (>10kb) Multiome | 525 | |
| chr7:139,027,051–139,027,458 | 8.6 kb | Proximal (<10kb) | 30 | |
| chr7:139,034,996–139,036,579 | 19 bp | At TSS Multiome | 626 | |
| chr7:139,090,840–139,094,844 | 57.7 kb | Distal (>10kb) Multiome | 732 | |
| chr7:139,108,547–139,110,090 | 73.6 kb | Distal (>10kb) Multiome | 920 | |
| chr7:139,124,120–139,124,640 | 88.4 kb | Distal (>10kb) Multiome | 304 | |
| chr7:139,133,422–139,134,016 | 97.7 kb | Distal (>10kb) Multiome | 936 | |
| chr7:139,230,473–139,232,505 | 195.1 kb | Distal (>10kb) Multiome | 971 |
Genomic view of the ZC3HAV1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.