Transcription factors with Perturb-seq knockdown data for ZBED5-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZBED5-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZBED5-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:10,735,514–10,736,088 | 122.3 kb | Distal (>10kb) Multiome | 637 | |
| chr11:10,750,622–10,751,770 | 107.1 kb | Distal (>10kb) Multiome | 974 | |
| chr11:10,792,316–10,792,962 | 65.6 kb | Distal (>10kb) Multiome | 530 | |
| chr11:10,807,818–10,809,752 | 49.2 kb | Distal (>10kb) Multiome | 1038 | |
| chr11:10,857,279–10,858,931 | 81 bp | At TSS Multiome | 958 | |
| chr11:10,930,673–10,932,142 | 73.1 kb | Distal (>10kb) Multiome | 512 | |
| chr11:10,933,806–10,934,381 | 75.9 kb | Distal (>10kb) Multiome | 447 |
Genomic view of the ZBED5-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.