This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for YWHAQ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YWHAQ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YWHAQ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,422,555–9,424,057 | 207.5 kb | Distal (>10kb) Multiome | 1016 | |
| chr2:9,473,505–9,475,238 | 156.3 kb | Distal (>10kb) Multiome | 602 | |
| chr2:9,475,498–9,477,288 | 154.2 kb | Distal (>10kb) Multiome | 228 | |
| chr2:9,554,934–9,556,567 | 75.1 kb | Distal (>10kb) Multiome | 1091 | |
| chr2:9,630,002–9,631,663 | 53 bp | At TSS Multiome | 995 | |
| chr2:9,632,020–9,632,239 | 1.4 kb | Proximal (<10kb) | 45 | |
| chr2:9,770,260–9,771,096 | 139.7 kb | Distal (>10kb) Multiome | 321 | |
| chr2:9,813,714–9,814,312 | 183.0 kb | Distal (>10kb) Multiome | 406 | |
| chr2:9,843,034–9,844,039 | 212.5 kb | Distal (>10kb) Multiome | 965 |
Genomic view of the YWHAQ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.