Predicted to enable metal ion binding activity. Predicted to act upstream of or within several processes, including negative regulation of erythrocyte clearance; negative regulation of erythrocyte differentiation; and protein localization to plasma membrane. Predicted to be located in nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for YPEL4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YPEL4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YPEL4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,637,508–57,640,656 | 9.3 kb | Proximal (<10kb) | 699 | |
| chr11:57,641,091–57,641,256 | 8.7 kb | Proximal (<10kb) | 70 | |
| chr11:57,641,577–57,641,788 | 8.2 kb | Proximal (<10kb) | 83 | |
| chr11:57,644,541–57,645,304 | 4.6 kb | Proximal (<10kb) | 237 | |
| chr11:57,645,540–57,646,495 | 3.4 kb | Proximal (<10kb) | 111 | |
| chr11:57,646,682–57,652,802 | at TSS | At TSS | 580 | |
| chr11:57,653,349–57,654,303 | 3.4 kb | Proximal (<10kb) | 37 | |
| chr11:57,656,843–57,658,231 | 6.9 kb | Proximal (<10kb) | 827 |
Genomic view of the YPEL4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.