This gene encodes a mitochondrial protein that catalyzes the attachment of tyrosine to tRNA(Tyr). Mutations in this gene are associated with myopathy with lactic acidosis and sideroblastic anemia type 2 (MLASA2). [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for YARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = YARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of YARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:32,501,832–32,502,447 | 253.8 kb | Distal (>10kb) Multiome | 347 | |
| chr12:32,678,963–32,680,020 | 76.6 kb | Distal (>10kb) Multiome | 960 | |
| chr12:32,754,967–32,756,883 | 615 bp | At TSS Multiome | 978 | |
| chr12:32,893,054–32,894,062 | 137.4 kb | Distal (>10kb) Multiome HiCAR | 249 | |
| chr12:32,896,168–32,897,592 | 141.0 kb | Distal (>10kb) Multiome HiCAR | 653 | |
| chr12:33,438,371–33,440,222 | 683.9 kb | Distal (>10kb) Multiome HiCAR | 377 | |
| chr12:34,022,100–34,023,125 | 1266.5 kb | Distal (>10kb) Multiome HiCAR | 645 |
Genomic view of the YARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.