This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for XRCC3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XRCC3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XRCC3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:103,456,058–103,456,564 | 259.1 kb | Distal (>10kb) Multiome | 49 | |
| chr14:103,518,427–103,519,043 | 196.7 kb | Distal (>10kb) Multiome | 404 | |
| chr14:103,520,443–103,523,552 | 192.6 kb | Distal (>10kb) Multiome | 756 | |
| chr14:103,528,671–103,529,619 | 186.3 kb | Distal (>10kb) Multiome | 726 | |
| chr14:103,561,982–103,563,356 | 152.6 kb | Distal (>10kb) Multiome | 781 | |
| chr14:103,628,110–103,630,126 | 86.3 kb | Distal (>10kb) Multiome | 909 | |
| chr14:103,715,029–103,716,504 | 165 bp | At TSS Multiome | 709 | |
| chr14:103,846,809–103,848,686 | 132.2 kb | Distal (>10kb) Multiome | 711 | |
| chr14:103,855,145–103,855,758 | 140.1 kb | Distal (>10kb) Multiome | 418 | |
| chr14:103,871,719–103,872,659 | 156.6 kb | Distal (>10kb) Multiome | 313 | |
| chr14:103,910,266–103,910,793 | 195.0 kb | Distal (>10kb) Multiome | 374 | |
| chr14:103,921,195–103,921,889 | 206.1 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the XRCC3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.