The protein encoded by this gene is a receptor for the xenotropic and polytropic classes of murine leukemia viruses. The encoded protein is involved in phosphate homeostasis by mediating phosphate export from the cell. Defects in this gene have been associated with idiopathic basal ganglia calcification-6. [provided by RefSeq, Jun 2016]
Transcription factors with Perturb-seq knockdown data for XPR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,501,987–180,503,224 | 129.4 kb | Distal (>10kb) Multiome | 1104 | |
| chr1:180,631,586–180,632,828 | 3 bp | At TSS Multiome | 843 | |
| chr1:180,639,769–180,640,641 | 8.0 kb | Proximal (<10kb) Multiome | 216 | |
| chr1:180,854,229–180,855,048 | 222.6 kb | Distal (>10kb) Multiome HiCAR | 299 | |
| chr1:180,911,688–180,913,578 | 280.9 kb | Distal (>10kb) Multiome | 364 | |
| chr1:180,922,741–180,923,870 | 291.3 kb | Distal (>10kb) Multiome | 265 | |
| chr1:181,142,277–181,142,792 | 510.6 kb | Distal (>10kb) Multiome HiCAR | 599 | |
| chr1:181,152,896–181,153,600 | 521.1 kb | Distal (>10kb) Multiome HiCAR | 502 | |
| chr1:181,166,371–181,166,866 | 534.7 kb | Distal (>10kb) Multiome HiCAR | 327 |
Genomic view of the XPR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.