XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
Transcription factors with Perturb-seq knockdown data for XPO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,525,162–20,526,319 | 376.9 kb | Distal (>10kb) Multiome HiCAR | 695 | |
| chr13:20,703,037–20,704,890 | 198.5 kb | Distal (>10kb) Multiome | 620 | |
| chr13:20,773,202–20,774,439 | 128.9 kb | Distal (>10kb) Multiome | 873 | |
| chr13:20,902,026–20,903,305 | 108 bp | At TSS Multiome | 749 | |
| chr13:21,060,253–21,061,988 | 158.8 kb | Distal (>10kb) Multiome | 817 | |
| chr13:21,075,367–21,076,193 | 173.1 kb | Distal (>10kb) Multiome | 151 | |
| chr13:21,139,877–21,141,067 | 237.7 kb | Distal (>10kb) Multiome | 784 | |
| chr13:21,176,109–21,177,241 | 273.9 kb | Distal (>10kb) Multiome | 933 |
Genomic view of the XPO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.