This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
Transcription factors with Perturb-seq knockdown data for XPNPEP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = XPNPEP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of XPNPEP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:109,883,984–109,884,981 | 39.1 kb | Distal (>10kb) Multiome | 460 | |
| chr10:109,913,452–109,913,704 | 9.8 kb | Proximal (<10kb) | 28 | |
| chr10:109,922,853–109,924,531 | 15 bp | At TSS Multiome | 670 | |
| chr10:109,934,169–109,935,521 | 11.6 kb | Distal (>10kb) Multiome | 274 | |
| chr10:109,996,780–109,997,611 | 73.8 kb | Distal (>10kb) Multiome | 150 | |
| chr10:110,006,797–110,009,028 | 84.4 kb | Distal (>10kb) Multiome | 867 | |
| chr10:110,081,755–110,082,396 | 158.6 kb | Distal (>10kb) Multiome | 288 | |
| chr10:110,168,513–110,169,827 | 245.7 kb | Distal (>10kb) Multiome | 325 | |
| chr10:110,181,115–110,182,697 | 258.1 kb | Distal (>10kb) Multiome | 325 | |
| chr10:110,205,984–110,208,438 | 284.1 kb | Distal (>10kb) Multiome | 727 | |
| chr10:110,209,115–110,211,789 | 286.3 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the XPNPEP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.