This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]
Transcription factors with Perturb-seq knockdown data for WRAP73. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WRAP73 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WRAP73, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,918,258–1,920,500 | 1730.6 kb | Distal (>10kb) Multiome HiCAR | 820 | |
| chr1:3,453,034–3,455,700 | 196.8 kb | Distal (>10kb) Multiome | 874 | |
| chr1:3,471,270–3,471,995 | 178.4 kb | Distal (>10kb) Multiome | 575 | |
| chr1:3,491,285–3,491,949 | 158.6 kb | Distal (>10kb) Multiome | 309 | |
| chr1:3,530,504–3,532,073 | 118.6 kb | Distal (>10kb) Multiome | 442 | |
| chr1:3,610,667–3,612,281 | 38.4 kb | Distal (>10kb) Multiome | 361 | |
| chr1:3,624,289–3,625,883 | 25.2 kb | Distal (>10kb) Multiome | 814 | |
| chr1:3,649,785–3,650,304 | 21 bp | At TSS Multiome | 620 | |
| chr1:3,650,851–3,651,788 | 788 bp | At TSS | 186 | |
| chr1:3,651,921–3,653,136 | 2.7 kb | Proximal (<10kb) Multiome | 369 | |
| chr1:3,746,744–3,747,607 | 97.3 kb | Distal (>10kb) Multiome | 523 | |
| chr1:3,771,515–3,773,363 | 122.5 kb | Distal (>10kb) Multiome | 733 | |
| chr1:3,793,373–3,793,897 | 143.6 kb | Distal (>10kb) Multiome | 182 | |
| chr1:3,795,866–3,796,907 | 146.5 kb | Distal (>10kb) Multiome | 835 | |
| chr1:3,856,527–3,858,218 | 207.3 kb | Distal (>10kb) Multiome | 815 | |
| chr1:3,899,608–3,901,755 | 251.3 kb | Distal (>10kb) Multiome | 1026 | |
| chr1:3,910,694–3,911,367 | 261.0 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the WRAP73 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.