This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for WNT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WNT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WNT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,369,701–112,370,152 | 139.1 kb | Distal (>10kb) Multiome | 364 | |
| chr1:112,390,678–112,391,531 | 118.0 kb | Distal (>10kb) Multiome | 470 | |
| chr1:112,395,753–112,396,890 | 112.8 kb | Distal (>10kb) Multiome | 600 | |
| chr1:112,465,931–112,466,532 | 42.7 kb | Distal (>10kb) Multiome | 686 | |
| chr1:112,501,804–112,502,551 | 6.8 kb | Proximal (<10kb) Multiome | 420 | |
| chr1:112,507,925–112,508,314 | 649 bp | At TSS | 122 | |
| chr1:112,508,429–112,509,558 | 5 bp | At TSS Multiome | 413 | |
| chr1:112,524,298–112,524,779 | 15.5 kb | Distal (>10kb) Multiome | 127 | |
| chr1:112,618,652–112,620,129 | 110.8 kb | Distal (>10kb) Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 166.4 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,700,203–112,701,476 | 191.9 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 196.2 kb | Distal (>10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 198.3 kb | Distal (>10kb) Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 207.7 kb | Distal (>10kb) Multiome | 765 | |
| chr1:112,790,881–112,791,569 | 282.3 kb | Distal (>10kb) Multiome | 158 |
Genomic view of the WNT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.