Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WEE2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WEE2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WEE2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:141,550,725–141,551,853 | 186.8 kb | Distal (>10kb) Multiome | 899 | |
| chr7:141,701,501–141,702,649 | 36.1 kb | Distal (>10kb) Multiome | 455 | |
| chr7:141,733,513–141,733,674 | 4.6 kb | Proximal (<10kb) | 14 | |
| chr7:141,737,828–141,738,838 | 34 bp | At TSS Multiome | 1117 | |
| chr7:141,975,843–141,976,803 | 238.1 kb | Distal (>10kb) Multiome | 357 | |
| chr7:141,994,100–141,994,957 | 256.4 kb | Distal (>10kb) Multiome | 70 |
Genomic view of the WEE2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.