This gene encodes a member of the WIPI or SVP1 family of WD40 repeat-containing proteins. The protein contains seven WD40 repeats that are thought to fold into a beta-propeller structure that mediates protein-protein interactions, and a conserved motif for interaction with phospholipids. The human genome contains several pseudogenes of this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR45B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR45B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR45B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:82,414,581–82,415,044 | 233.6 kb | Distal (>10kb) Multiome | 799 | |
| chr17:82,417,993–82,419,018 | 229.9 kb | Distal (>10kb) Multiome | 844 | |
| chr17:82,450,369–82,451,002 | 197.6 kb | Distal (>10kb) Multiome | 837 | |
| chr17:82,458,067–82,459,318 | 189.9 kb | Distal (>10kb) Multiome | 1054 | |
| chr17:82,494,122–82,495,128 | 153.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr17:82,496,968–82,497,781 | 151.1 kb | Distal (>10kb) Multiome | 613 | |
| chr17:82,519,154–82,520,226 | 128.9 kb | Distal (>10kb) Multiome | 869 | |
| chr17:82,647,682–82,648,684 | 175 bp | At TSS Multiome | 874 | |
| chr17:82,648,831–82,649,423 | 387 bp | At TSS | 240 | |
| chr17:82,697,983–82,699,271 | 50.4 kb | Distal (>10kb) Multiome | 623 | |
| chr17:82,715,983–82,717,178 | 68.1 kb | Distal (>10kb) Multiome | 744 | |
| chr17:82,735,174–82,736,034 | 87.1 kb | Distal (>10kb) Multiome | 649 | |
| chr17:82,751,094–82,752,780 | 103.3 kb | Distal (>10kb) Multiome | 987 | |
| chr17:82,754,710–82,755,244 | 106.5 kb | Distal (>10kb) Multiome | 188 |
Genomic view of the WDR45B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.